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Changes in mRNA Expression by schedule-dependent combination of 5-FU and selumetinib

ABSTRACT: Anti-tumor effect of the combination between 5-FU and selumetinib was treatment schedule-dependent in BRAF or KRAS mutant CRC cells. Treatment of 5-FU for 2 days followed by selumetinib for another 2 days exhibited synergism for cell viability, whereas single or reversely combined treatment showed antagonism Microarray analysis revealed the distinct groups of genes underlying the efficacy for schedule-dependent treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE89531 | GEO | 2020/12/30

REPOSITORIES: GEO

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