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Cbx3 Maintains Lineage Specificity During Neural Differentiation [ChIP-seq]

ABSTRACT: Cbx3 (HP1γ) that is a member of the heterochromatin protein 1 familiy enriched in gene bodies of pluripotent ESCs but promoters of differentiated pre-iPSCs. To determine whether Cbx3 becomes enriched at promoters to influence gene regulation during differentiation, we converted ESCs to NPCs in monolayer culuture and performed genomewide ChIP-seq of Cbx3. Our results shows that Cbx3 enriches at the promoters of genes upon differentiation of ESCs to NPCs and stablizes the binding of Mediator subunit Med26 to pre-initiation complex (PIC) in NPCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE89573 | GEO | 2017/03/27

SECONDARY ACCESSION(S): PRJNA352607

REPOSITORIES: GEO

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