Transcriptomics,Genomics

Dataset Information

107

The molecular basis of CD4 T-cell help for the cytotoxic T-cell response


ABSTRACT: CD4+ T cells optimize the cytotoxic T cell (CTL) response in magnitude and quality, by unknown molecular mechanisms. We here present the transcriptomic changes, resulting from CD4+ T-cell help during priming, as apparent in effector CTLs. This gene expression signature reveals that CD4+ T-cell help optimizes CTLs in the expression of cytotoxic effector molecules, but also in many other functions that ensure optimal efficacy of CTLs throughout their life cycle. Overall design: Whole transcriptome analysis of effector CD8 T cells primed in the presence or absence of CD4 T cell help after vaccination or virus infection, or treated with agonistic CD27 or blocking CD70 antibody after vaccination.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Tomasz Ahrends 

PROVIDER: GSE89665 | GEO | 2017-11-07

SECONDARY ACCESSION(S): PRJNA352860

REPOSITORIES: GEO

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Publications

CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.

Ahrends Tomasz T   Spanjaard Aldo A   Pilzecker Bas B   Bąbała Nikolina N   Bovens Astrid A   Xiao Yanling Y   Jacobs Heinz H   Borst Jannie J  

Immunity 20171107 5


CD4+ T cells optimize the cytotoxic T cell (CTL) response in magnitude and quality, by unknown molecular mechanisms. We here present the transcriptomic changes in CTLs resulting from CD4+ T cell help after anti-cancer vaccination or virus infection. The gene expression signatures revealed that CD4+ T cell help during priming optimized CTLs in expression of cytotoxic effector molecules and many other functions that ensured efficacy of CTLs throughout their life cycle. Key features included downre  ...[more]

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