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Inflammatory markers in ABCG1-/- lungs

ABSTRACT: Transcriptional profiling of cytokines and its receptors in lungs from 8 month old chow-fed wild-type and ABCG1-/- mice Keywords: genotype comparison; inflammatory mediators

ORGANISM(S): Mus musculus

PROVIDER: GSE8976 | GEO | 2008/07/30

SECONDARY ACCESSION(S): PRJNA102433

REPOSITORIES: GEO

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Inflammatory markers in ABCG1-/- lungs

Project description:Transcriptional profiling of cytokines and its receptors in lungs from 8 month old chow-fed wild-type and ABCG1-/- mice Keywords: genotype comparison; inflammatory mediators 4 individual mice per group; RNA from inferior left lobe; WT vs. ABCG1-/-

2010-05-25 | E-GEOD-8976 | biostudies-arrayexpress

Adrenal Abcg1 controls cholesterol flux and steroidogenesis

Project description:Cholesterol is the precursor of all steroids, but how cholesterol flux is controlled in steroidogenic tissues is poorly understood. The cholesterol exporter ABCG1 is an essential component of the reverse cholesterol pathway and its systemic inactivation results in neutral lipid redistribution to macrophages. However, the function of ABCG1 in steroidogenic organs is not explored. To model this question, we inactivated the ortholog Abcg1 gene in the mouse adrenal cortex. Abcg1 disruption led to an adrenal-specific increase in transcripts involved in cholesterol uptake and de novo synthesis, and to an 80% increase in corticosterone production. Importantly, this phenotype was not recapitulated by inactivation of the cholesterol exporter Abca1. The absence of any change in lipid profile suggested that adrenal Abcg1 is not involved in cholesterol export to a clinically relevant extent.

2023-09-05 | GSE242081 | GEO

Effects of deletioin of cholesterol efflux genes Abca1 and Abcg1 on other gene expressions in macrophages

Project description:ATP binding cassette subfamily member 1 (ABCA1) and G1 (ABCG1) are cholesterol efflux transporter to prevent excess intracellular cholesterol accumulation. We here report the deletion of Abca1 and Abcg1 results in the significant increased expression of Cd38, a multi-faceted ectoenzyme with NADase activity.

2024-04-17 | GSE234507 | GEO

Mus musculus

Project description:Inflammatory markers in ABCG1-/- lungs

| PRJNA102433 | ENA

Adrenal Abcg1 controls cholesterol flux and steroidogenesis

Project description:Adrenal Abcg1 controls cholesterol flux and steroidogenesis

| PRJNA1011305 | ENA

Single cell RNA sequencing of myeloid cells from lungs of young and aged mice

Project description:Single cell RNA sequencing from lungs of young (2-3 month old) and aged (20-22 month old) mice.

2021-10-20 | GSE167236 | GEO

Oxaliplatin resistance is enhanced by saracatinib via upregulation of ABCG1 and Wnt/β-catenin signaling in hepatocellular carcinoma

Project description:Background:Oxaliplatin-resistant hepatocellular carcinoma (HCC) is associated with increased insulin-like growth factor 1 (IGF1) paracrine signaling, and the IGF1 receptor can be downregulated by inhibition of Src kinases. Therefore, we sought to determine whether Src inhibition and oxaliplatin treatment exerted synergistic effects on HCC cell lines. Methods: The antitumor effects of combined treatment with saracatinib and oxaliplatin on proliferation were evaluated in HCC cells as well as in saracatinib- and oxaliplatin-resistant HCC cell lines using cell viability assays, plate colony formation assays, and cell cycle distribution detection. RNA sequencing was used to explore the resistance mechanism, and the effects on ABCG1 and Wnt signaling in oxaliplatin resistance were confirmed. Results: Chemotherapy with oxaliplatin and saracatinib individually induced strong anti-HCC effects, while combined or sequential treatment of HCC cells with these two drugs exhibited reduced efficacy compared to treatment with the single drugs. Furthermore, treatment with saracatinib caused oxaliplatin resistance. RNA sequencing revealed 458 genes that were altered by treatment with saracatinib and oxaliplatin. Of these, the gene encoding the ATP-binding cassette transporter G1 ABCG1 and Wnt-associated genes were significantly upregulated. Upregulation of ABCG1 and oxaliplatin resistance were associated with activation of Wnt signaling. Interference with ABCG1 expression or inhibition of Wnt signaling resulted in reversal of the saracatinib-induced oxaliplatin resistance in the HCC cell lines. Conclusions: These studies demonstrated that combined or sequential chemotherapy with oxaliplatin and saracatinib reduced antitumor efficacy, and this antagonism was attributed to the upregulation of ABCG1 and activation of Wnt signaling pathway by saracatinib.

2019-03-30 | GSE129071 | GEO

ABCG1

Project description:Arabidopsis thaliana ABCG1, ABC transporter G family member 1 [Source:UniProtKB/Swiss-Prot;Acc:O80946], is expressed in 16 baseline experiment(s);

| AT2G39350 | ExpressionAtlas

ABCG1

Project description:Arabidopsis thaliana ABCG1, ABC transporter G family member 1 [Source:UniProtKB/Swiss-Prot;Acc:O80946], is differentially expressed in 124 experiment(s);

| AT2G39350 | ExpressionAtlas

Abcg1

Project description:Rattus norvegicus Abcg1, ATP binding cassette subfamily G member 1 [Source:RGD Symbol;Acc:620294], is differentially expressed in 30 experiment(s);

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