Dataset Information


Gene Expression of PS19 Tau transgenic mice

ABSTRACT: Expression of PS19 Tau Transgenic mice from hippocampus at different ages 3, 6, 9, and 12 months We used Affy arrays to understand the global expression profile of PS19 Tau transgenic mice Overall design: Total RNA from hippocampi samples of PS19 Tau transgenic and wild-type littermates were isolated at various ages and affymetrix microarray were run. Gene expression at the probe ID levels were collapsed using collapseRows function in WGCNA package, R and trajectory of salmon and turquoise modules were evaluated using module eigengene function, WGCNA package, R

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

ORGANISM(S): Mus musculus  

SUBMITTER: Vivek Swarup  

PROVIDER: GSE89979 | GEO | 2018-08-28


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Identifying the mechanisms through which genetic risk causes dementia is an imperative for new therapeutic development. Here, we apply a multistage, systems biology approach to elucidate the disease mechanisms in frontotemporal dementia. We identify two gene coexpression modules that are preserved in mice harboring mutations in MAPT, GRN and other dementia mutations on diverse genetic backgrounds. We bridge the species divide via integration with proteomic and transcriptomic data from the human  ...[more]

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