Project description:Copy number variations (CNVs) can create new genes, change gene dosage, reshape gene structures, and modify elements regulating gene expression. As with all types of genetic variation, CNVs may influence phenotypic variation and gene expression. CNVs are thus considered major sources of genetic variation. Little is known, however, about their contribution to genetic variation in rice. To detect CNVs, we used a set of NimbleGen whole-genome comparative genomic hybridization arrays containing 715,851 oligonucleotide probes with a median probe spacing of 500 bp. We compiled a high-resolution map of CNVs in the rice genome, showing 641 CNVs between the genomes of the rice cultivars ‘Nipponbare’ (from O. sativa ssp. japonica) and ‘Guang-lu-ai 4’ (from O. sativa ssp. indica). These CNVs contain some known genes. They are linked to variation among rice varieties, and are likely to contribute to subspecific characteristics.

2012-07-01 | GSE30542 | GEO

Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arrays.

Project description: Not available

| S-EPMC1665641 | biostudies-literature

A novel technique for measuring variations in DNA copy-number: competitive genomic polymerase chain reaction.

Project description: Not available

| S-EPMC1920520 | biostudies-literature