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EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE90045 | GEO | 2016/11/18

SECONDARY ACCESSION(S): PRJNA354401

REPOSITORIES: GEO

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EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.

Project description: Not available

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EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (EPOP KO)

Project description:Gene regulatory networks are pivotal for many biological processes. In mouse embryonic stem cells (mESCs) the transcriptional network can be divided into three functionally distinct modules: Polycomb, Core and Myc. The Polycomb module represses developmental genes, while the Myc module is associated with proliferative functions and its mis-regulation is linked to cancer development. Here, we show that in mESCs the Polycomb Repressive Complex 2 (PRC2) associated protein EPOP (a.k.a C17orf96, esPRC2p48, E130012A19Rik) co-localizes at chromatin with members of the Myc and Polycomb module. EPOP interacts with the transcription elongation factor Elongin BC and the H2B deubiquitinase USP7 to modulate transcriptional processes in mESCs similar to MYC. EPOP is commonly up-regulated in human cancer and we demonstrate that its loss impairs the proliferation of several human cancer cell lines. Our findings establish EPOP as a unique modulator of transcriptional processes, impacting both Polycomb and active gene transcription in mammalian cells.

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EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (USP7 KO)

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EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (Elongin B KO)

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EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape

Project description:EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape

| PRJNA354401 | ENA

EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (EPOP KO)

Project description:EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (EPOP KO)

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EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells

Project description:The cellular plasticity of pluripotent stem cells is thought to be sustained by genomic regions that display both active and repressive chromatin properties. These regions exhibit low levels of gene expression, yet the mechanisms controlling these levels remain unknown. Here, we describe Elongin BC as a binding factor at the promoters of bivalent sites. Biochemical and genome-wide analysis shows that Elongin BC is associated with Polycomb Repressive Complex 2 (PRC2) in pluripotent stem cells. Elongin BC is recruited to chromatin by the PRC2-associated factor EPOP (Elongin- and POlycomb-associated Protein, also termed C17orf96, esPRC2p48, E130012A19Rik), a protein expressed in the inner cell mass of the mouse blastocyst. Both EPOP and Elongin BC are required to maintain low levels of expression at PRC2 genomic targets. Our results indicate that keeping the balance between activating and repressive cues is a more general feature of chromatin in pluripotent stem cells than previously appreciated.

2016-11-21 | GSE79606 | GEO

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons

Project description:This SuperSeries is composed of the SubSeries listed below.

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

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Placing the HIRA histone chaperone complex in the chromatin landscape

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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