Ribosome profiling of G2019S LRRK2 human dopamine neurons

ABSTRACT: G2019S mutaion of LRRK2 is known to increase mRNA translation. We perform ribosome profiling to study defective translation using human dopamine neuron models. Patient-derived human dopamine neurons with G2019S LRRK2 mutation were generated and used. Also a mutation-corrected isogenic pair line was used.

ORGANISM(S): Homo sapiens

PROVIDER: GSE90469 | GEO | 2018/07/01

REPOSITORIES: GEO