Transcriptomics,Genomics

Dataset Information

38

MicroRNA expression data from CIE-vapor treated mice


ABSTRACT: We examined microRNA expression profiles in amygdala (AMY), nucleus accumbens (NAC) and prefrontal cortex (PFC) of male C57BL/6J mice exposed to 4 cycles of chronic intermittent ethanol (CIE) vapor. Animals were sacrificed at 0, 8, and 120 hr following the last ethanol exposure. Overall design: Mice were exposed to 4 cycles of intermittent vapor [4 days of 16 hours vapor/ 8 hours air] with a week between each cycle. Before entry into the vapor chambers, animals were injected with pyrazole (1 mMol/kg) and either ethanol (1.6 g/kg) or saline (controls). Animals were sacrificed at 0, 8, and 120 hr following the last ethanol exposure. All groups contained 8 animals except: AMY 120hr control (7 animals), NAC 0hr CIE-treated (7 animals), NAC 8hr control (6 animals), PFC 0hr control (7 animals)

INSTRUMENT(S): [miRNA-3] Affymetrix Multispecies miRNA-3 Array

SUBMITTER: Elizabeth Osterndorff-Kahanek 

PROVIDER: GSE90608 | GEO | 2017-12-01

SECONDARY ACCESSION(S): PRJNA355169

REPOSITORIES: GEO

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Publications

Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain.

Osterndorff-Kahanek Elizabeth A EA   Tiwari Gayatri R GR   Lopez Marcelo F MF   Becker Howard C HC   Harris R Adron RA   Mayfield R Dayne RD  

PloS one 20180109 1


Long-term alcohol use can result in lasting changes in brain function, ultimately leading to alcohol dependence. These functional alterations arise from dysregulation of complex gene networks, and growing evidence implicates microRNAs as key regulators of these networks. We examined time- and brain region-dependent changes in microRNA expression after chronic intermittent ethanol (CIE) exposure in C57BL/6J mice. Animals were sacrificed at 0, 8, and 120h following the last exposure to four weekly  ...[more]

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