Genomics

Dataset Information

0

Systemic human ILC precursors provide a substrate for tissue ILC differentiation


ABSTRACT: Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCP). Still, how ILCP relate to mature tissue-resident ILCs remains unclear. We identify ILCP that are present in the blood and all tested lymphoid and non-lymphoid human tissues. Human ILCP fail to express the signature transcription factors (TF) and cytokine outputs of mature NK cells and ILCs but are epigenetically poised to do so. Human ILCP robustly generate all ILC subsets in vitro and in vivo. While human ILCP express RAR related orphan receptor C (RORC), circulating ILCP can be found in RORC-deficient patients that retain potential for EOMES+ NK cells, T-BET+ ILC1, GATA-3+ ILC2 and for IL-22+ but not for IL-17A+ ILC3. We propose a model of tissue ILC differentiation (‘ILC-poiesis’) whereby diverse ILC subsets are generated in situ from ILCP in response to environmental stressors, inflammation and infection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE90640 | GEO | 2017/03/19

SECONDARY ACCESSION(S): PRJNA355273

REPOSITORIES: GEO

Similar Datasets

2021-11-05 | GSE186950 | GEO
2023-06-07 | GSE203002 | GEO
2017-03-19 | GSE90834 | GEO
2020-11-20 | GSE160009 | GEO
| E-GEOD-29777 | biostudies-arrayexpress
2019-05-11 | GSE131038 | GEO
2022-02-17 | GSE176367 | GEO
2023-09-01 | GSE225168 | GEO
2023-09-01 | GSE225167 | GEO
2023-10-10 | PXD037817 | Pride