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Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids II

ABSTRACT: We have mapped regulatory loci for nearly all protein coding genes in the mammalian genome using microarray measurements from a panel of mouse/hamster radiation hybrids. Proof of principle transfection experiment. Pcdh7 (a gene identified as being a regulator of many genes) is transfected into A23 and HEK cells and compared to A23 and HEK cells transfected with an empty vector. Upregulated genes predicted by our approach are compared with the transfection experiments Keywords: tranfection, regulation of gene expression

ORGANISM(S): Mus musculus Homo sapiens Cricetulus griseus

PROVIDER: GSE9066 | GEO | 2008/03/13

SECONDARY ACCESSION(S): PRJNA105325

REPOSITORIES: GEO

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Transcription profiling of human HEK cells and hamster A23 cells transfected with Pcdh7 (a gene identified as a regulator of many genes) or empty vector to validate results of prediction of upregulated genes

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