Genomics

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Impact of melatonin on gene expression in colonic epithelium of pinealectomized rats


ABSTRACT: To examine the effect of melatonin on global gene expression in the colonic epithelium, we used RNA-seq analysis to identify differentially expressed genes (DEGs) in samples from three melatonin-treated (MEL4-6) versus three vehicle-treated pinealectomized rats (VEH1-3) injected i.p. at the beginning of subjective night and sacrificed 4 h later. More than 12 050 expressed genes were identified in each sample out of 18 258 genes in the database. A surprisingly small number of significant DEGs (49) was identified. The GO pathways analysis revealed that the largest group of the DEGs was associated with immune system response. Most DEGs (47) identified by RNA-seq were independently analyzed by RT-qPCR and the correlation between both methods indicates reliability of the data.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE90837 | GEO | 2016/12/04

SECONDARY ACCESSION(S): PRJNA356122

REPOSITORIES: GEO

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