Dataset Information


XBP-1 transduction of PEL

ABSTRACT: Transcription of human and KSHV genes in PEL following the transduction of spliced and unspliced XBP-1 Keywords: Cell type comparison Overall design: Two colour sample Cy5, reference Cy3, reference is a mixture of mRNA from uninfected, HeLa cell and KSHV lytic cycle induced PEL.

INSTRUMENT(S): Host and Pathogen Microarray

SUBMITTER: Paul Kellam  

PROVIDER: GSE9096 | GEO | 2007-09-28



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X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency.

Wilson Sam J SJ   Tsao Edward H EH   Webb Benjamin L J BL   Ye Hongtao H   Dalton-Griffin Lucy L   Tsantoulas Christoforos C   Gale Catherine V CV   Du Ming-Qing MQ   Whitehouse Adrian A   Kellam Paul P  

Journal of virology 20071010 24

Reactivation of lytic replication from viral latency is a defining property of all herpesviruses. Despite this, the authentic physiological cues for the latent-lytic switch are unclear. Such cues should ensure that viral lytic replication occurs under physiological conditions, predominantly in sites which facilitate transmission to permissive uninfected cells and new susceptible hosts. Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with the B-cell neoplasm primary effusion lymphoma  ...[more]

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