Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Variation of genome-wide NF-kappa B RELA binding sites in response to different microbial stimuli

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE91020 | GEO | 2018/01/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Variation of genome-wide NF-kappa B RELA binding sites in response to different microbial stimuli

Project description:Variation of genome-wide NF-kappa B RELA binding sites in response to different microbial stimuli

| PRJNA356686 | ENA

Genome-wide RELA binding sites in response to 5 microbial stimuli in Detroit562 cells [ChIP-seq]

Project description:NFKB is a family of transcription factors (TF), which are master regulators of the innate immune system. It is activated downstream of pathogen recognition receptors after ligand binding and regulates the expression of antimicrobials, cytokines and chemokines, thus helping to fight infections as well as recruiting the adaptive immune system. Although NFKB responds to a wide variety of signals, the processes in which stimulus-specificity is attained are still unclear. Here, we characterized the response of one of the NFKB members, RELA, to five stimuli mimicking infection in nasopharyngeal epithelial cells. When comparing RELA genome-wide binding sites , we detected most of them to be overlapping among the different stimulations. Yet, we distinguished a minority of stimulus-specific RELA binding sites. Interestingly, some of these seemed to have a biological effect as they correlated with corresponding gene expression. Specifically, the response to Poly I:C mimicking viral dsRNA gave a distinct RELA profile binding the vicinity of antiviral genes. This group of binding sites was also enriched in Interferon Regulatory Factor motifs indicating that the interaction with more specialized TFs could contribute to stimulus-specific RELA activity. Furthermore, motif analysis revealed differences in the sequence of the NFKB motifs between certain stimulus-specific sets of peaks suggesting preferences for particular NFKB dimers in response to defined signals.

2018-01-30 | GSE91018 | GEO

Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses.

Project description: Not available

| S-EPMC3067974 | biostudies-literature

RelA-Containing NF?B Dimers Have Strikingly Different DNA-Binding Cavities in the Absence of DNA.

Project description: Not available

| S-EPMC5951767 | biostudies-literature

NF-kappaB RelA phosphorylation regulates RelA acetylation.

Project description: Not available

| S-EPMC1234328 | biostudies-literature

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry.

Project description: Not available

| S-EPMC4633404 | biostudies-literature

Genome wide binding sites of NF-κB subunits RelA, RelB, p50, and p52 in the Hodgkin lymphoma cell line L1236

Project description:The malignant cells of Hodgkin's lymphoma are characterized by a constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We carried out genome-wide localization and expression profiling experiments in the Hodgkin lymphoma cell line L1236 for the canonical and non-canonical NF-κB pathway components p65, p50 and p52, RelB, respectively. We found that the single NF-κB subunits bind to overlapping, but distinct cistromes by using consensus motifs of high similarity.

2016-02-18 | GSE63736 | GEO

Genome wide binding sites of NF-ÎºB subunits RelA, RelB, p50, and p52 in the Hodgkin lymphoma cell line L1236

Project description:The malignant cells of Hodgkin's lymphoma are characterized by a constitutive activation of the canonical as well as the non-canonical NF-ÎºB signaling cascades. We carried out genome-wide localization and expression profiling experiments in the Hodgkin lymphoma cell line L1236 for the canonical and non-canonical NF-ÎºB pathway components p65, p50 and p52, RelB, respectively. We found that the single NF-ÎºB subunits bind to overlapping, but distinct cistromes by using consensus motifs of high similarity. ChIP-Seq analysis of 4 NF-ÎºB subunits with 2 biological replicates each

2016-02-18 | E-GEOD-63736 | biostudies-arrayexpress

Genome-wide maps of XBP1 binding sites in different breast cancer cell lines

Project description: Not available

| S-ECPF-GEOD-49955 | biostudies-other

Enterovirus 71 2C Protein Inhibits NF-?B Activation by Binding to RelA(p65).

Project description: Not available

| S-EPMC4585786 | biostudies-literature