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Global transcriptional profiling confirmed failed decidualization of human Endometrial Stromal Cells (hESCs) obtained from non-pregnant women with a previous pregnancy complicated by severe preeclampsia (sPE).

ABSTRACT: The data presented here suggested that sPE is associated with impaired decidualization. Initial experiments involved an in vitro approach. hESCs were isolated from patients who developed sPE in a previous pregnancy or control women who had normal obstetric outcomes. Function was tested by comparing the ability of hESCs in the two groups to decidualize in culture. By morphological criteria and marker expression (PRL and IGFBP1), the cells in the formerly sPE group were decidualization resistant, which was confirmed by microarray analyses showing that they were transcriptionally inert.

ORGANISM(S): Homo sapiens

PROVIDER: GSE91077 | GEO | 2016/12/16

SECONDARY ACCESSION(S): PRJNA356828

REPOSITORIES: GEO

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