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Differential gene expression in primary ovarian tumors from depressed and non-depressed patients

ABSTRACT: Gene expression profiling was carried out on primary ovarian carcinomas from 10 patients. The primary research question is whether gene expression differs in tissues from individuals with high vs low symptoms of psychological depression. Keywords: Risk prediction

ORGANISM(S): Homo sapiens

PROVIDER: GSE9116 | GEO | 2008/09/10

SECONDARY ACCESSION(S): PRJNA102647

REPOSITORIES: GEO

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Transcription profiling of primary ovarian tumors from depressed and non-depressed patients

Project description:Gene expression profiling was carried out on primary ovarian carcinomas from 10 patients. The primary research question is whether gene expression differs in tissues from individuals with high vs low symptoms of psychological depression. Experiment Overall Design: Gene expression profiling was carried out on primary ovarian carcinomas from 10 patients. The primary research question is whether gene expression differs in tissues from individuals with high vs low symptoms of psychological depression.

2008-10-25 | E-GEOD-9116 | biostudies-arrayexpress

Leukocyte gene expression in depressed and non-depressed renal cell carcinoma patients

Project description:Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from renal cell carcinoma patients. The primary research question is whether gene expression differs as a function of patient's level of depression as measured by CESD score > 16. Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from renal cell carcinoma patients. The primary research question is whether gene expression differs as a function of patient's level of depression as measured by CESD score > 16.

2013-04-01 | E-GEOD-36957 | biostudies-arrayexpress

Leukocyte gene expression in depressed and non-depressed renal cell carcinoma patients

2013-04-01 | GSE36957 | GEO

Differential gene expression in circulating leukocytes from chronically lonely individuals

Project description:Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 93 older adults participating in the Chicago Health Aging and Social Relations Study (CHASRS). The primary research question is whether gene expression differs in participants who are chronically lonely. Keywords: Risk prediction Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 93 older adults participating in the Chicago Health Aging and Social Relations Study (CHASRS). The primary research question is whether gene expression differs in participants who are chronically lonely.

2011-03-16 | E-GEOD-25837 | biostudies-arrayexpress

The role microglia in electroconvulsive threapy (ECT) in depressed-like mice

Project description:Recent studies implicate microglia alterations in the pathogenesis and pathophysiology of depression. For example, chronic unpredictable stress (CUS) in mice can cause degeneration of microglia and depressive-like symptoms, which can be reversed by microglia stimulating drugs. To further test the causal role of microglia in CUS-induced depression and its reversal by an anti-depressive procedure, we examined the effects of microglia depletion with the CSF-1 antagonist PLX5622 or pharmacological blockade of microglial activation with minocycline on normal mood-related behavior, CUS-induced depressive-like symptoms, and the amelioration of these symptoms by electroconvulsive treatment (ECT). We report that microglia-depleted mice showed no depression, anxiety or spatial memory disturbances. Microglia depletion had no effect on the development of CUS-induced depressive-like symptoms and suppressed neurogenesis, but it completely abrogated the beneficial effects of ECT on depression and neurogenesis, as well as on the all ECT-induced transcriptomic changes. ECT induced several morphological changes in microglia, suggestive of increased activation status, and blockade of this activation by minocycline attenuated the anti-depressive and pro-neurogenesis effect of ECT and reduced the number of contacts between microglia and neurogenic cells. The immune checkpoint gene Lag3, whose expression by microglia was increased following CUS, was the only microglial transcript significantly reduced by ECT. Furthermore, treatment of depressed-like mice with a LAG3 monoclonal antibody was further tested.

2021-01-01 | GSE123027 | GEO

Differential gene expression in peripheral blood leukocytes as a function of estrogen

Project description:Gene expression profiling was carried out on peripheral blood mononuclear cells from 45 adult females. The primary research question is whether leukocyte gene expression differs in individuals with varying levels of estrogen signaling. Keywords: Risk prediction

2009-08-10 | GSE12517 | GEO

Differential gene expression in peripheral blood CD14+ leukocytes from SRESS study particpants

Project description:Gene expression profiling was carried out on peripheral blood CD14+ leukocytes from 21 stressed caregivers and controls (all adult). The primary research question is whether gene expression differs in individuals from high stress vs low stress environments. Keywords: Risk prediction

2008-05-20 | GSE7893 | GEO

Differential gene expression in peripheral blood CD2+ leukocytes from PATH particpants

Project description:Gene expression profiling was carried out on peripheral blood CD2+ leukocytes from 29 children with asthma. The primary research question is whether gene expression differs in individuals from high socioeconomic status environments vs low socioeconomic status environments. Keywords: Risk prediction

2009-05-26 | GSE7894 | GEO

Differential gene expression in circulating leukocytes from breast cancer patients treated with Cognitive Behavioral Stress Management

Project description:Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 53 female breast cancer patients at 6- or 12-month follow-ups in a randomized controlled trial of Cognitive Behavioral Stress Management or an active control condition. The primary research question is whether gene expression differs in patients treated with Cogntive Behavioral Stress Management vs control conditions. Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 53 female breast cancer patients at 6- or 12-month follow-ups in a randomized controlled trial of Cognitive Behavioral Stress Management or an active control condition. The primary research question is whether gene expression differs in patients treated with Cogntive Behavioral Stress Management vs control conditions. Risk prediction

2012-01-01 | E-GEOD-24079 | biostudies-arrayexpress

Differential gene expression in peripheral blood leukocytes from CHASRS particpants

Project description:Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation. Keywords: Risk prediction

2007-11-02 | GSE7148 | GEO

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