Genomics

Dataset Information

0

X chromosome-specific Array-CGH of XLMR patient


ABSTRACT: Mental retardation (MR) is a non-progressive cognitive impairment affecting 2 to 3% of the Western population. So far, point mutations and subtle deletions and insertions have been shown to represent only a proportion (<40%) of genetic causes underlying X-linked mental retardation (XLMR). We have screened a subset of 300 presumable X-linked families by X chromosome-specific array-CGH and identified 6 families with overlapping microduplications at Xp11.22 containing two candidate genes; both of which showed overexpression in the affected individuals. Array-CGH data revealed aberrant Cy5/Cy3 log2 ratios for different but overlapping sets of clones indicating varying sizes of these duplications in the different families. Keywords: comparative genomic hybridization

ORGANISM(S): Homo sapiens

PROVIDER: GSE9143 | GEO | 2008/02/20

SECONDARY ACCESSION(S): PRJNA102685

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-9143 | biostudies-arrayexpress
2010-08-17 | GSE17813 | GEO
| E-GEOD-17813 | biostudies-arrayexpress
2007-07-04 | GSE7886 | GEO
2006-10-22 | GSE4884 | GEO
2007-05-22 | GSE6225 | GEO
2007-03-12 | GSE7226 | GEO
2009-07-29 | GSE17369 | GEO
2008-05-27 | GSE10049 | GEO
| E-GEOD-17369 | biostudies-arrayexpress