Dataset Information


Gene alterations by PPAR-gamma agonists in human colorectal adenocarcinoma HCT-116 cells

ABSTRACT: We examined the alternation of gene expression by MCC-555, rosiglitazone (RGZ) and 15-deoxy-?12, 14-prostaglandin J2 (PGJ2) in human colorectal adenocarcinoma HCT-116 cells. Keywords: effects of PPAR-gamma agonists Overall design: Common control: DMSO as a vehicle treatement in human colorectal adenocarcinoma HCT-116 cells; Samples: Three PPAR-gamma ligand treatments in HCT-116 cells.

INSTRUMENT(S): HEEBO Human oligo array

SUBMITTER: Seung Joon Baek  

PROVIDER: GSE9183 | GEO | 2008-06-10



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Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cells.

Cekanova Maria M   Yuan Joshua S JS   Li Xiuoon X   Kim Kyubo K   Baek Seung Joon SJ  

International journal of oncology 20080401 4

The peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear transcription factor that controls the genes involved in metabolism and carcinogenesis. In the present study, we examined the alteration of gene expression in HCT-116 human colorectal cancer cells by PPARgamma agonists: MCC-555 (5 microM), rosiglitazone (5 microM), and 15-deoxy-Delta12,14-prostaglandin J2 (1 microM). The long-oligo microarray data revealed a list of target genes commonly induced (307 genes) and repress  ...[more]

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