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Expression of Cell Cycle related genes in developing mouse cerebellum

ABSTRACT: The goal of the study was to analize expression of cell cycle related genes during postnatal development of Ts65Dn (Down syndrome mouse model) and control mice cerebellum. Keywords: Gene expression study in mouse model of disease

ORGANISM(S): Mus musculus

PROVIDER: GSE9216 | GEO | 2008/05/19

SECONDARY ACCESSION(S): PRJNA102807

REPOSITORIES: GEO

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Expression of Cell Cycle related genes in developing mouse cerebellum

Project description:The goal of the study was to analize expression of cell cycle related genes during postnatal development of Ts65Dn (Down syndrome mouse model) and control mice cerebellum. Keywords: Gene expression study in mouse model of disease RNA from 3 controls and 3 Ts65Dn postnatal day 2 cerebellum were analized on separate arrays.

2008-05-18 | E-GEOD-9216 | biostudies-arrayexpress

Postnatal day 6 cerebellum of Ts65Dn and TcMAC21 Down syndrome mouse models

Project description:Postnatal day 6 cerebellum of Ts65Dn and TcMAC21 Down syndrome mouse models

| PRJNA837794 | ENA

Transcriptome of Ts1Cje and euploids cerebellum

Project description:Transcriptome analysis of Ts1Cje (mouse model of Down syndrome) and euploids murine cerebellum during postnatal development Keywords = Down syndrome Keywords = Chromosome 21 Keywords = Transcriptome Keywords = Microarray Keywords = Cerebellum Keywords = Development Keywords: other

2004-12-05 | GSE1611 | GEO

Single-Cell Transcriptomes Reveal Molecular Specializations of Neuronal Cell Types in the Developing Cerebellum

Project description:We analyzed transcriptome profiles of 21,119 single cells of the postnatal mouse cerebellum and identified 8 main cell clusters (Granule precursors, Granule cells, Astrocytes, Interneurons, Oligodendrocytes, Microglia, Purkinje cells, Endothelial cells).

2019-03-12 | GSE122357 | GEO

Implication of Nos2 inactivation on the transcriptome of developing cerebellum and Ptch1+/- medulloblastomas (mRNA)

Project description:The Ptch1+/- strain constitues an established mouse model for the Shh-driven type of medulloblastoma. Combined Ptch1+/- Nos2-/- mice show a two-fold increased incidence for this tumor. Here, the impact of Nos2 inactivation on medulloblastoma development was investigated by gene expression profiling of tumor samples as well as healthy cerebellum at different ages and genotypes. Medulloblastoma samples from three Ptch1+/- and six combined Ptch1+/- Nos2-/- mice were analyzed. Healthy cerebellum taken from mice at postnatal day nine, six weeks after birth, and about 1 year of age were analyzed for wildtype animals and the genotypes Ptch1+/-, Ptch1+/- Nos2-/-, and Nos2-/-. The cerebellar developmental stages at six weeks and one year were measured in three biological replicates, while samples taken at postnatal day six consisted of pooled individual specimen. These were measured in three replicates being amplified and labelled in separate reactions. All samples were subjected to two-color hybridizations against Universal Reference RNA (Stratagene) with color-switch experiments yielding two technical replicates, respectively.

2011-12-01 | E-GEOD-29192 | biostudies-arrayexpress

Cerebellum of Lurcher (Lc +/-) mouse.

Project description:Analysis of gene expression in cerebellum of postnatal day 10 Lurcher (Lc +/-) mouse, compared to wild type littermate. Keywords: other

2003-03-24 | GSE352 | GEO

Transcription profiling by array of mouse Ts1Cje (mouse model of Down syndrome) and euploids murine cerebellum during postnatal development

2004-12-05 | E-GEOD-1611 | biostudies-arrayexpress

RNaseH2B single and compound mutant cerebellum

Project description:We utilized RNA-seq analysis to examine the loss of RNaseH2B in the mouse cerebellum over time. We have looked at single and compound mutant knockouts at ages from postnatal day five, postnatal day twenty-eight and nine-week-old animals.

2021-10-01 | GSE181159 | GEO

Postnatal day 6 cerebellum of Ts65Dn and TcMAC21 Down syndrome mouse models

Project description:Dysregulation of Sonic hedgehog (SHH) signaling may contribute to multiple Down syndrome-associated phenotypes, including cerebellar hypoplasia, congenital heart defects, craniofacial and skeletal dysmorphologies, and Hirschsprung disease. Granule cell precursors isolated from the developing cerebellum of Ts65Dn mice are less responsive to the mitogenic effects of SHH than euploid cells, and a single postnatal dose of the SHH pathway agonist SAG rescues cerebellar morphology and performance on learning and memory tasks in Ts65Dn mice. SAG treatment also normalizes expression levels of OLIG2 in neural progenitor cells derived from human trisomy 21 iPSCs. However, despite evidence that activating SHH signaling rescues Down syndrome-associated phenotypes, chromosome 21 does not encode any canonical components of the SHH pathway. Here, we screened 163 chromosome 21 cDNAs in a series of SHH-responsive cell lines to identify chromosome 21 genes that modulate SHH signaling and confirmed overexpression of trisomic candidate genes using RNA-seq in Ts65Dn and TcMAC21 cerebellum. Our study indicates that some chromosome 21 genes, including DYRK1A, activate SHH signaling while others, such as HMGN1 and MIS18A, inhibit SHH signaling. Moreover, overexpression of genes involved in chromatin structure and mitosis, but not genes previously implicated in ciliogenesis, regulate the SHH pathway. Our data suggest that cerebellar hypoplasia and other phenotypes related to aberrant SHH signaling arise from the net effect of trisomy for multiple chromosome 21 genes rather than the overexpression of a single trisomic gene. Identifying which chromosome 21 genes modulate SHH signaling may also suggest new therapeutic avenues for ameliorating Down syndrome phenotypes.

2022-05-16 | GSE202938 | GEO

Cerebellum of Lurcher (Lc +/-) mouse.

Project description:Analysis of gene expression in cerebellum of postnatal day 10 Lurcher (Lc +/-) mouse, compared to wild type littermate. Keywords: other

2003-03-23 | E-GEOD-352 | biostudies-arrayexpress

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