Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The impact of Tcf1/Lef1 deficiency and prostagladin E (PGE) treatment on leukemic stem cell (LSC) transcriptome

ABSTRACT: Comparison of trasncriptome bewteen control LSCs and Tcf1/Lef1 deficient LSCs, LSCs treated with DMSO, PGE1 or PGE2.

ORGANISM(S): Mus musculus

PROVIDER: GSE92361 | GEO | 2017/07/31

SECONDARY ACCESSION(S): PRJNA357379

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Impact of Tcf1 and Lef1 deficiency on histone marks and Tcf1 binding in CD8 T cells

Project description:Comparison of epigenome and Tcf1 occupancy between control and Tcf1/Lef1-deficient CD8 T cells Control mice or those are deficient for Tcf1 and Lef1 transcription factors (deleted by CD4-Cre) were used to isolate thymocytes. The thymocytes were surface-stained to identify TCRbeta high, CD69â, CD24â CD8+ subsets. These cells were sorted for ChIPseq analysis of various histone marks. Control mice or those are deficient for Tcf1 (deleted by CD4-Cre) were used to isolate thymocytes. The splenocytes were surface-stained to identify TCRbeta high, CD8+ subsets. These cells were sorted for ChIPseq analysis of Tcf1 binding locations.

2016-02-12 | E-GEOD-73239 | biostudies-arrayexpress

Impact of Tcf1 and Lef1 deficiency on mature CD8 thymocytes

Project description:Comparison of transcriptome between control and Tcf1/Lef1-deficient mature CD8 thymocytes Control mice or those are deficient for Tcf1 and Lef1 transcription factors (deleted by CD4-Cre) were used to isolate thymocytes. The thymocytes were surface-stained to identify TCRbeta high, CD69â, CD24â CD8+ subsets. These cells were sorted for RNAseq analysis.

2016-02-12 | E-GEOD-73238 | biostudies-arrayexpress

Impact of Tcf1/Lef1 deficiency on Treg cells

Project description:Comparison of transcriptome between control and Tcf1/Lef1-deficient Treg cells

2019-02-14 | GSE119769 | GEO

Impact of Tcf1 and Lef1 deficiency on histone marks and Tcf1 binding in CD8 T cells

Project description:Comparison of epigenome and Tcf1 occupancy between control and Tcf1/Lef1-deficient CD8 T cells

2016-02-12 | GSE73239 | GEO

Impact of Tcf1 and Lef1 deficiency on HSCs

Project description:Comparison of transcriptome between control and Tcf1/Lef1-deficient hematopoietic stem cells (HSCs).

2017-08-08 | GSE60587 | GEO

Tcf1 and Lef1 regulate follicular helper T cell function eliciated by vaccination [ATAC-Seq]

Project description:The goal of this study is to determine the impact of Tcf1 and Lef1 deficiency on T follicular helper (Tfh) cells elicited by protein immunization. We demonstrate that although phenotypic Tcf1/Lef1-deficient Tfh cells were able to develop in response to vaccination, they are functionally impaired. Mechanisc studies reveal the direct regulatory effect by Tcf1 and Lef1 on transcriptome and chromatin accessibility in vaccine-elicited Tfh cells. Analysis of chromatin accessibility in WT and Tcf1/Lef1-deficient Tfh cells eliciated by vaccination.

2020-10-19 | GSE146421 | GEO

Tcf1 and Lef1 regulate follicular helper T cell function eliciated by vaccination [CUTnRUN]

2020-10-19 | GSE146422 | GEO

Impact of Tcf1 and Lef1 deficiency on mature CD8 thymocytes

Project description:Comparison of transcriptome between control and Tcf1/Lef1-deficient mature CD8 thymocytes

2016-02-12 | GSE73238 | GEO

Tcf1 and Lef1 regulate follicular helper T cell function eliciated by vaccination [RNA-Seq]

2020-10-19 | GSE146425 | GEO

Tcf1/Lef1 transcription factors and CD8 T cell identity [RNA-seq]

Project description:Comparison of transcriptomes between WT and Tcf1/Lef1-deficient naïve CD8+ T cells

2021-07-11 | GSE164712 | GEO