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Expression data from mouse naïve (Naive), stem cell memory (TSCM), central memory (TCM) CD4+ T cells

ABSTRACT: Stem cell memory T cells can be defined as the memory T cell subsets with naïve T cell phenotypes and stem cell-like properties. We find that Notch signaling converts activated T cells into stem cell memory T (TSCM) cells by OP9-DL1 feeder cell coculture. Based on gene expression profile analysis, we provide evidence that these cells represent distinct characters with central memory T (TCM) cells and naïve T cells with effector molecules and transcription factors. TSCM cells induced by Notch cluster closer to TCM cells than naïve T cells, and display similar phenotypes to TCM phenotype in terms of effector molecules and transcription factors, but the gene expressions of TSCM cells are entirely lower than that of TCM cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE92381 | GEO | 2016/12/15

SECONDARY ACCESSION(S): PRJNA357382

REPOSITORIES: GEO

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