TGF-beta signalling through SMAD1/5 is required for epithelial-to-mesenchymal transition

ABSTRACT: TGF-beta treatment leads to SMAD1/5 phosphorylation. However, the ability of SMAD1/5 to bind chromatin downstream of TGF-beta signalling is unknown. We performed ChIP-sequencing for pSMAD1/5 and SMAD3 to identify binding sites for pSMAD1/5 upon TGF-beta stimulation and identified preferential pSMAD1/5 binding at SMAD1/5:SMAD4 consensus sites.

ORGANISM(S): Homo sapiens

PROVIDER: GSE92443 | GEO | 2018/02/16

REPOSITORIES: GEO