Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression analysis in primary murine Alveolar type II cells under Normoxia 21% O2 and Hyperoxia 85% O2 after 6 hours and 24 hours

ABSTRACT: In this study the gene expression of primary murine (C57BL/6) lung alveolar type II cells belonging to four different conditions was analyzed. Effects of hyperoxia 24 hours group (group 2) were compared to the normoxia 24 hours (group 1) and effects of the hyperoxia 6 hours group (group 4) were compared to the normoxia 6 hours (group 3)

ORGANISM(S): Mus musculus

PROVIDER: GSE92552 | GEO | 2017/12/16

SECONDARY ACCESSION(S): PRJNA358034

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

microRNA expression in primary murine Alveolar type II cells under Normoxia 21% O2 and Hyperoxia 85% O2 after 6 hours and 24 hours

Project description:In this study the microRNA expression of primary murine (C57BL/6) lung alveolar type II cells belonging to four different conditions was analyzed. Effects of hyperoxia 24 hours group were compared to the normoxia 24 hours and effects of the hyperoxia 6 hours group were compared to the normoxia 6 hours.

2017-12-16 | GSE92551 | GEO

Normoxia and Hyperoxia time series

Project description:These are two time-series of affymetrix MOE430A microarrays of mouse retina ranging from 7 to 12 days. The two conditions are normoxia and hyperoxia Keywords: time-course

2008-08-18 | GSE1816 | GEO

RNA-sequencing analysis reveals mitochondrial dysfunction in Akap1 Knockout mice exposed to hyperoxia

Project description:Akap1 KO and Wt mice were exposed to normoxia or hyperoxia for 48h. Total RNA was extracted from lungs of Wt Normoxia (n=3), Wt hyperoxia (n=3), Akap1 KO (n=3) and Akap1 hyperoxia (n=3) mice. RNA-sequencing was carried out followed by differential expression of genes in the following groups. Wt Normoxia vs Wt Hyperoxia, Akap1 KO Normoxia versus Akap1 KO Hyperoxia, Wt Normoxia versus Akap1 KO Normoxia and Wt Hperoxia versus Akap1 Hyperoxia.

2022-10-26 | GSE173295 | GEO

Fgf10 knock-down effects in hyperoxia and normoxia

Project description:Fgf10 knock-down effects in hyperoxia and normoxia

| PRJNA450014 | ENA

Differential microRNA gene expression between normal and aberrant late lung development induced by hyperoxia in mice

Project description:Newborn mouse pups were exposed either to normoxia (21% O2) or to hyperoxia (85% O2) since the day of birth. Lungs were harvested at P2.5, P3.5, P5.5 and P14.5 and homogenized for a downstream microRNA (miR) microarray in order to compare the differential expression of miRs between normoxia and hyperoxia group. Several miRs appeared to be dysregulated, mainly and with a higher significance, at P5.5 and P14.5.

2017-02-25 | GSE89666 | GEO

Meythlation profiling by array to investigate the effect of hyperoxia on DNA methylation in mouse lung tissue

Project description:Hyperoxia has a potential to alter DNA methylation status. We assessed the effect of long term hyperoxia in mouse lung tissue. A total of 24 mice were randomized to hyperoxia (85% O2; 12 animals) or normoxia (21% O2; 12 animals) for 14 days continued with normoxia conditions for all animals for the subsequent 14 days. All mice had free access to food and water and were kept under standard conditions in A-Chambers (O2 – monitor ProOX110, CO2 – monitor ProCO2 P120, BioSpherix). The animals were sacrificed on day 28. Lung tissue was harvested on day 28 after euthanasia with a zolazepam/tiletamine/xylazine/fentanyl cocktail. Tissues samples were snap-frozen in liquid nitrogen immediately after cessation of circulation for the subsequent analysis. Subsequently, DNA methylation profiles in lung tissue were compared by means of methylation microarrays between both groups. We used the Genomic Workbench software (Agilent) to assess the mean methylation status of each DNA fragment (array probe) in each group. We first calculated the normalised, combined Z-scores, representing summation of the left and right Gaussian Z-scores and reflecting the location of a probe log-ratio value in relation to the Gaussian distribution of probes. A strong positive value of the combined Z-score means that a given probe is methylated and strong negative value means that it is unmethylated. Next, we compared the mean combined Z-scores (average methylation patterns) of the probes between hyperoxia and normoxia groups.

2018-02-17 | E-MTAB-6489 | biostudies-arrayexpress

Comparison of hypoxia (4 % O2) cultured human embryonic stem cells (hESCs) to normoxia (21 % O2) cultured

Project description:We compared the transcriptome at gene expression level in hypoxic and normoxic conditions. The transcriptome of cells cultured at three different timepoints, 2h, 24 h and 7 days with three different cell lines in normoxia and hypoxia was compared

2014-01-02 | GSE35819 | GEO

Comparison of hypoxia (4 % O2) cultured human embryonic stem cells (hESCs) to normoxia (21 % O2) cultured

2014-01-02 | E-GEOD-35819 | biostudies-arrayexpress

Gene expression signatures for hyperoxia in lung cancer cell lines

Project description:Gene profile of normoxia (20% O2) was compared with that of hyperoxia (50% O2) in lung cancer cell lines.

2017-08-17 | GSE102705 | GEO

Transcription profiling of mouse retina after normoxia and hypoxia - time series

Project description:These are two time-series of affymetrix MOE430A microarrays of mouse retina ranging from 7 to 12 days. The two conditions are normoxia and hyperoxia

2008-10-25 | E-GEOD-1816 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data