Tsc2 KO cells have a transcriptional signature found in bladder tumors with TSC1/2 deficiency and that is corrected by sirolimus and includes Lgals3 overexpression

ABSTRACT: Use RNA-seq to obtain transcriptional signature of Tsc2 KO neonatal mouse dermal fibroblasts +/- sirolimus. The resulting mTORC1 transcriptional signature is tested in the TCGA database of bladder cancers with non-silent mutations in TSC1/2.

ORGANISM(S): Mus musculus

PROVIDER: GSE92589 | GEO | 2017/06/29

SECONDARY ACCESSION(S): PRJNA358080

REPOSITORIES: GEO