Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency

ABSTRACT: Phf5a regulates transcription elongation in mouse embryonic stem cells (ESCs), through regulation of the Paf1 complex. In this study we assayed for genome-wide localization of H2BK120-ub in mouse ESCs under conditions of shControl and shPhf5a knockdown. These results revealed that downregualtion of Phf5a results in the increase of the elongation mark H2BK120-ub from the gene bodies of pluripotency genes in ESC.

ORGANISM(S): Mus musculus

PROVIDER: GSE92727 | GEO | 2017/12/22

SECONDARY ACCESSION(S): PRJNA358475

REPOSITORIES: GEO