Genomics

Dataset Information

42

Genome-wide DNA-methylation profiles of human lung cancer cell lines and normal lung cells


ABSTRACT: Genome-wide DNA-methylation profiles of human lung cancer cell lines and normal lung cells were generated by Infinium bead chip technology DNA methylation patterns of over 480,000 CpG sites were analyzed in normal human bronchial epithelial cells (NHBEC) and three non small cell lung cancer cell lines (NSCLC: A427, A549 and H322) using bisulfite-based Illumina 450K BeadChip arrays Overall design: Three lung cancer cell lines (A549, A427 and H322), normal bronchial ephitelial cells (NHBEC)

INSTRUMENT(S): Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

SUBMITTER: Marek Bartkuhn  

PROVIDER: GSE92843 | GEO | 2017-08-15

SECONDARY ACCESSION(S): PRJNA358606

REPOSITORIES: GEO

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Publications

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer.

Kiehl Steffen S   Zimmermann Tobias T   Savai Rajkumar R   Pullamsetti Soni S SS   Seeger Werner W   Bartkuhn Marek M   Dammann Reinhard H RH  

Scientific reports 20170620 1


Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. It was observed that intra- and intergenic CGI exhibited higher methylation compared to normal cells. The functional annotation of hypermethylated CGI revealed that the hypermethylation was associated with homeobox domain genes and targets marked by repressive histone modificatio  ...[more]

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