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GPCR19 agonist increases in number of immune-regulatory myeloid cells and their expression of immune checkpoint molecule

ABSTRACT: GPCR19 pathway has been implicated in regulating various inflammation. However, the exact mechanism of immune regulation by GPCR19 pathway has not been elucidated in detail. Here, we report that intravenous infusion of a GPCR19 agonist, sodium taurodeoxycholate (STDC), decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury and prolongs mice survival during sepsis.

ORGANISM(S): Mus musculus

PROVIDER: GSE92948 | GEO | 2018/12/26

REPOSITORIES: GEO

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