Genomics

Dataset Information

0

A protective function of IL-22BP in acute liver injury


ABSTRACT: Acute liver injury is a critical life-threatening event. Common causes are infections, intoxication, and ischemic conditions. The cytokine Interleukin 22 (IL-22) has been implicated in this process. However, the role of IL-22 during acute liver damage is controversial, since both protective and pathogenic properties have been reported. IL-22 binding protein (IL-22BP, IL-22Ra2), a soluble endogenous inhibitor of IL-22, is able to regulate IL-22 activity, and thus might explain some of the controversial findings. Since the role of IL-22BP in liver injury is unknown, we used Il22bp deficient mice and mouse models for acute liver damage to address this point. We found that Il22bp deficient mice were more susceptible to ischemia- and acetaminophen- induced liver damage. Deficiency of Il22bp caused increased hepatic damage and delayed liver regeneration. Using an unbiased approach, we found that IL-22, if uncontrolled in Il22bp deficient mice, induced Cxcl10 expression by hepatocytes, thereby recruiting inflammatory CD11b+Ly6C+ monocytes into the liver upon liver damage. Accordingly, neutralization of Cxcl10 reversed the increased disease susceptibility of Il22bp deficient mice. In conclusion, our data suggest dual functions of IL-22 in acute liver damage, and highlight the need to control IL-22 activity via IL-22BP.

ORGANISM(S): Mus musculus

PROVIDER: GSE93034 | GEO | 2017/12/22

SECONDARY ACCESSION(S): PRJNA359494

REPOSITORIES: GEO

Similar Datasets

2021-06-11 | PXD021853 | Pride
2020-12-22 | GSE148309 | GEO
2023-01-10 | GSE217223 | GEO
2015-05-01 | E-GEOD-37468 | biostudies-arrayexpress
2022-06-21 | GSE163290 | GEO
2015-05-01 | E-GEOD-37559 | biostudies-arrayexpress
2014-10-16 | E-GEOD-62362 | biostudies-arrayexpress
2016-07-03 | E-GEOD-51389 | biostudies-arrayexpress
2015-05-01 | GSE37468 | GEO
2015-10-26 | E-GEOD-62760 | biostudies-arrayexpress