Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Acyclic retinoid induction of HepG2 cells

ABSTRACT: Acyclic retinoid induction of HepG2 cells Keywords: other

ORGANISM(S): Homo sapiens

PROVIDER: GSE931 | GEO | 2004/04/03

SECONDARY ACCESSION(S): PRJNA87961

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Acyclic retinoid induction of HepG2 cells

Project description:Acyclic retinoid induction of HepG2 cells

2010-06-09 | E-GEOD-931 | biostudies-arrayexpress

Homo sapiens

Project description:Acyclic retinoid induction of HepG2 cells

| PRJNA87961 | ENA

Gene expression of human hepatocellular carcinoma cells in response to acyclic retinoid

Project description:To better understand the molecular basis of the anticancer effects of acyclic retinoid (ACR), a genome-wide screening was applied to identify novel targets of ACR in human hepatocellular carcinoma (HCC) cells JHH7. Gene expression profiles of JHH7 were measured at 0h, 1h and 4 hours after treatment with1 μM All-trans retinoic acid (AtRA) or 10 μM ACR. Hierarchical clustering with Ward’s method of 44,907 genes demonstrated diverse expression changes in HCC cells treated with ACR for 4h. A total of 973 differentially expressed genes in response to ACR by comparing with AtRA for 4h treatments were identified with a fold change more than 2. Then, network analysis was performed on the altered gene expression profiles using Ingenuity Pathways Analysis (IPA) program. The most highly populated networks were associated with the regulation of cell cycle and DNA replication, as ACR is well known to induce apoptosis and suppress cell proliferation in HCC cells. Moreover, networks related with amino acid metabolism, protein synthesis and lipid metabolism, such as the biological network entitled “Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism” were also observed. Of interest, this network contains genes that play critical roles in controlling the development of tissues and organs such as the nuclear orphan receptor nuclear receptor subfamily 2, group F, member 2 (NR2F2), suggesting potential drug targets to prevent/treat HCC.

2015-08-08 | GSE71856 | GEO

Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development

Project description:Gene expression profiling in non tumor lesion in the liver of patients prior to administering peretinoin was unrelated to the clinical outcome, however, gene expression profiling 8 weeks after starting peretinoin therapy significantly predicted the recurrence of HCC Peretinoin, a member of the acyclic retinoid family, is expected to be an effective chemo preventive drug for HCC.The patients had undergone curative surgical resection or radiofrequency ablation (RFA). They received 300 mg/day or 600 mg/day of peretinoin for 8 weeks and were followed up for 88 weeks with 600 mg/day of peretinoin. Hepatic gene expression profiling obtained from non tumor lesion of these patients prior to administering peretinoin and 8 weeks after starting peretinoin treatment

2012-08-19 | E-GEOD-29302 | biostudies-arrayexpress

Gene expression of human hepatocellular carcinoma cells in response to acyclic retinoid

2015-08-08 | E-GEOD-71856 | biostudies-arrayexpress

Role of coactivator SRC-1/NcoA-1 for IL-6 target gene induction in HepG2 cells

Project description:This experiment series addresses the role of coactivator SRC-1/NcoA-1 for the induction of interleukin-6 (IL-6) target genes in HepG2 cells. For that purpose, HepG2 human hepatocellular carcinoma cells were manipulated to stably express an shRNA that knocks down SRC-1 expression yielding the HepG2-∆Src1 cells. Either unmanipulated HepG2 or HepG2-∆Src1 cells were then treated for various periods with IL-6. Keywords: time course, genetic modification

2006-12-31 | GSE4885 | GEO

Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.

Project description: Not available

| S-EPMC3024303 | biostudies-literature

Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression

Project description:Focused on the cytochromes P450 (CYPs), we studied gene expression changes in mice treated with acyclic nucleoside antivirals adefovir and tenofovir. Positive control group was treated by prototypic CYP inducers phenobarbital and beta-naphthoflavone. Expression profiling with Steroltalk cDNA arrays revealed major changes in CYP mRNA expression in the inducers-treated group but only minor changes in CYP expression in the adefovir and tenofovir groups.

2014-06-03 | GSE47698 | GEO

Single cell transcriptomics of lung retinoid-containing cells

Project description:Single cell transcriptomics of lung retinoid-containing cells

| PRJNA815685 | ENA

Single cell transcriptomics of lung retinoid-containing cells

Project description:We undertook single cell RNA sequencing (scRNA-seq) and bioinformatic analyses to identify roles for different alveolar cell populations in retinoid metabolism and storage.

2022-03-15 | GSE198521 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data