Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice

ABSTRACT: We report the effect of NAFLD on liver gene expression changes that could impact tetrachloroethhylene metabolism Methods: We fed male C57Bl/6J mice a base diet (BD), high fat (HFD), or methionine/choline/folate deficient high fat diet (MCD) for 8 weeks and then treated them with vehicle or tetrachloroethylene (PERC, 300 mg/kg ig). We only report "basal" differences herein (aka vehicle-treated). Results: We report that there were diet-specific differences in xenobiotic metabolizing genes, and that these genes may be responsible for NAFLD-induced disruption in PERC metabolism

ORGANISM(S): Mus musculus

PROVIDER: GSE93132 | GEO | 2017/01/05

SECONDARY ACCESSION(S): PRJNA360108

REPOSITORIES: GEO