Genomics

Dataset Information

27

Bazedoxifene and conjugated estrogen combination improves gut-liver axis health


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Karen Chen  

PROVIDER: GSE93137 | GEO | 2018-02-15

SECONDARY ACCESSION(S): GSE92968

REPOSITORIES: GEO

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Publications

Bazedoxifene and conjugated estrogen combination maintains metabolic homeostasis and benefits liver health.

Chen Karen Lee Ann KLA   Zhao Yiru Chen YC   Hieronymi Kadriye K   Smith Brandi Patricia BP   Madak-Erdogan Zeynep Z  

PloS one 20171221 12


The bazedoxifene and conjugated estrogens (CE+BZA) combination has been shown to prevent visceral adiposity and weight gain after ovariectomy. However, its impact on the liver transcriptomes associated with prevention of hepatosteatosis is yet to be determined. In the present study, we use liver transcriptomics and plasma metabolomics analysis to characterize the effects of various estrogens on liver. The CE+BZA combination was very effective at preventing ovariectomy-induced weight gain in mice  ...[more]

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