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Bazedoxifene and conjugated estrogen combination improves gut-liver axis health

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): mouse gut metagenome Mus musculus

PROVIDER: GSE93137 | GEO | 2018/02/15

REPOSITORIES: GEO

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Bazedoxifene and conjugated estrogen combination improves gut-liver axis health [microbiota]

Project description:Bazedoxifene and conjugated estrogens (CE+BZA) combination has been shown to prevent visceral adiposity and weight gain after menopause. However, its interaction with the microbiota has yet to be examined. In the present study, we use several –omics technologies to characterize the effects of various estrogens on the health of gut-liver axis. As reported in previous studies, CE+BZA combination is very effective at preventing ovariectomy-induced weight gain in mice fed a high-fat diet. Additionally, CE+BZA induces unique liver transcriptomic and blood metabolite profiles compared to estradiol, conjugated estrogens alone, and bazedoxifene alone. Several pathways and metabolites influenced are associated with lower rates of inflammation and overall benefits to gut and liver health. Finally, microbiome analysis shows that several bacterial species that potentially metabolize estrogens and affect their half-life in the body were significantly changed in CE+BZA treated mice. Our findings indicate a possible link between certain estrogens and gut microbiome and suggest a metabolic benefit of estrogens through manipulation of the gut-liver axis.

2019-12-28 | GSE93096 | GEO