Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of drugs on transcriptomic profiles

ABSTRACT: the goal of this project is to determine the impact on genome-wide RNA expression of two molecules with biomedical applications on cancer

ORGANISM(S): Homo sapiens

PROVIDER: GSE93206 | GEO | 2017/03/01

SECONDARY ACCESSION(S): PRJNA360294

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Transcriptomic profiles of seven M. abscessus isolates during log growth

Project description:The goal of this sequencing project was to measure transcription levels of the bacterial genes, prophages and plasmids

2021-03-03 | GSE161710 | GEO

Transcriptomic profiling of human senescent cells in the setting of pharmacological intervention (NAD+ and NMN)

Project description:Aging and age-relataed pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using small molecules would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of two metabolic molecules, NAD+ and NMN, to control the development of the pro-inflammatory phenotype of senescent human stromal cells. This study discloses the impact of NAD+ and NMN on the expression profile of senescent cells and provides a framework for future anti-aging administration with clear rationale.

2022-12-31 | GSE156038 | GEO

Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications

Project description:Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of functionality. Therefore, in this study, we established a perfusable culture system based on in vivo-like heart microenvironments to improve human cardiac tissue fabrication. The integrated culture platform of a microfluidic chip and a three-dimensional heart extracellular matrix enhanced human cardiac tissue development and their structural and functional maturation. These tissues were comprised of cardiovascular lineage cells, including cardiomyocytes and cardiac fibroblasts derived from human induced pluripotent stem cells, as well as vascular endothelial cells. The resultant macroscale human cardiac tissues exhibited improved efficacy in drug testing (small molecules with various levels of arrhythmia risk), disease modeling (long QT syndrome and cardiac fibrosis), and regenerative therapy (myocardial infarction treatment). Therefore, our culture system can serve as a highly effective tissue-engineering platform to provide human cardiac tissues for versatile biomedical applications.

2024-02-03 | PXD042077 | Pride

Comparison of Lung Cancer Proteome Profiles 3: DIA

Project description:The goal of this project is to compare label free quantification, chemical labeling with tandem mass tags, and data independent acquisition discovery proteomics approaches using lung squamous cell carcinomas and adjacent lung tissues.

2017-02-16 | PXD004684 | Pride

Comparison of Lung Cancer Proteome Profiles 2: TMT

2017-02-16 | PXD004683 | Pride

Basic study about the effect of neoadjuvant chemotherapy on the biomarker profiles Additional study of phase II trial of neoadjuvant chemotherapy for unresectable liver metastasis of colorectal cancer

Project description:Primary outcome(s): Changes of biomarker molecules on the genetic and protein levels

| 2622691 | ecrin-mdr-crc

Transcriptomic profile of LadyBird mycobacteriophage lysogen

Project description:The goal of this sequencing project was to identify genes and ncRNAs expressed by the LadyBird prophage

2020-02-22 | GSE145724 | GEO

Achilles Heels of Senescent Cells: From Transcriptome to Senolytic Drugs

Project description:The healthspan of mice is enhanced by selectively killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and burden of age-related chronic diseases. As senescent cells resist apoptosis, we used microarrays to identify transcripts and pathways that differ between senescent and non-senescent preadipocytes, and might be involved in resistance to apoptosis.

2015-03-10 | GSE66236 | GEO

Transcriptomic study in mog1 yeast mutant

Project description:The goal of the project was to study the effects on transctiptome of some mutations related with SAGA complex

2018-08-31 | GSE109435 | GEO

Comparison of Lung Cancer Proteome Profiles 1: Label Free Quantification

2017-02-16 | PXD004682 | Pride