Genomics

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Pentachlorophenol treatment with 50 uM for 2 h


ABSTRACT: The number and type of synthetic chemicals that are being produced worldwide continues to increase significantly. While these industrial chemicals provide numerous benefits, there is no doubt that some have potential to damage the environment and health. Toxicity must be evaluated and use must be carefully controlled and monitored in order to minimize potential damage. DNA microarray technology has become an important new technique in toxicology. We are using the yeast Saccharomyces cerevisiae as a model organism for toxicological study because it is a simple, fast-growing eukaryote that has been thoroughly characterized. In order to evaluate toxicity by newly synthesized or mixture chemicals, toxicity-induced gene expression alteration profiles by known chemicals should be collected. In our study, cells need to be exposed with same experimental cellular condition, semi lethal (IC50), respectively. In the case of pentachlorophenol (CAS; 87-86-5), the exposure dose was decided as 50 uM by growth curve with continuously diluted exposure. Pentachlorophenol is a pesticide (fungicides) that is recognized as a carcinogen and suspected to be cardiovascular or blood toxicant, developmental toxicant, endocrine toxicant, gastrointestinal or liver toxicant, immunotoxicant, kidney toxicant, neurotoxicant, reproductive toxicant, respiratory toxicant and skin or sense organ toxicant. Keywords: stress response

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE9323 | GEO | 2007/11/01

SECONDARY ACCESSION(S): PRJNA102991

REPOSITORIES: GEO

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