Net silencing by let-7i in Postural Tachycardia Syndrome

ABSTRACT: While strongly implicated in Postural Tachycardia Syndrome (POTS), considerable controversy exists regarding norepinephrine transporter (NET) loss-of-function. POTS is characterized by the clinical symptoms of orthostatic intolerance, light-headedness, tachycardia and syncope or near syncope with upright posture. Abnormal sympathetic nervous system activity is typical, of a type which suggests dysfunction of the NET, with evidence the gene responsible is under tight epigenetic control. Using RNA of isolated chromatin combined with sequencing (RICh-Seq) we show let7i miRNA suppresses NET by MeCP2. Vorinostat restores epigenetic control and NET expression in POTS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE93235 | GEO | 2017/01/07

SECONDARY ACCESSION(S): PRJNA360387

REPOSITORIES: GEO