Gene expression profile in stable RCAN1-4 knockdown thyroid cancer cell lines
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ABSTRACT: To explore the effects of endogenous RCAN1-4 loss on thyroid cancer in vivo, we developed RCAN1-4 knockdown stable cells. Subcutaneous xenograft models demonstrated that RCAN1-4 knockdown promotes tumor growth. Intravenous metastasis models demonstrated that RCAN1-4 loss promotes tumor metastases to the lungs and their subsequent growth. Microarray was performed to understand how RCAN1-4 regulates tumor behaviors and the global effects of RCAN1-4 knockdown in these cells.
ORGANISM(S): Homo sapiens
PROVIDER: GSE93250 | GEO | 2017/04/07
SECONDARY ACCESSION(S): PRJNA360419
REPOSITORIES: GEO
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