Gene expression profile of T-DM1 resistant and parental cell lines
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ABSTRACT: The esophageal cancer cell line OE-19 was used to select resistant cells to T-DM1. They were selected by prolonged exposure to increasing concentrations of T-DM1 in the absence or presence of ciclosporin A (CsA). Two cell lines resulted from these experimental conditions: OE-19 TR in the absence of CsA and OE-19 TCR in the presence of CsA. The parental cell line was named OE-19 S. The present study aims to detect the transcriptomic changes between OE-19 S, OE-19 TR and OE-19 TCR cell lines to identify the deregulated pathways involved in acquired resistance to T-DM1.
ORGANISM(S): Homo sapiens
PROVIDER: GSE93352 | GEO | 2017/01/11
SECONDARY ACCESSION(S): PRJNA360676
REPOSITORIES: GEO
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