Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential responses of human fetal brain neural stem cells to Zika virus infection

ABSTRACT: Purpose: The goal of this study is to investigate the effect of Zika virus infection on neural stem cells Methods: RNA-Seq transcriptome analysis of neural stem cells infected with Zika virus compared to mock infected

ORGANISM(S): Homo sapiens

PROVIDER: GSE93385 | GEO | 2017/02/17

SECONDARY ACCESSION(S): PRJNA360845

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Zika virus infections of porcine fetal brain

Project description:Zika virus was inoculated at mid gestation (day 50) in to either intra cerebrally, or interperotoneally and intra amniotic. Controls were mock injected and subject to similar surgical proceedures. Fetal tissue were obtained. Sampled fetal brains are from littermates and are not the fetus directly infected. After 28 days post infection.

2017-09-18 | GSE103932 | GEO

Zika infected neural stem cells

Project description:Zika infected neural stem cells

| PRJNA453491 | ENA

Transcriptome analysis of Zika infected neural stem cells

Project description:RNA-seq was utilized to characterize the transcriptome of human neural stem cells infected with Zika virus strains MR766 and Paraiba at MOI 1. Coding and noncoding genes were analyzed to determine transcriptional changes 3 days post-infection.

2019-06-18 | GSE113636 | GEO

miRNA analysis of Zika infected neural stem cells

Project description:small RNA-seq was utilized to characterize the transcriptome of human neural stem cells infected with Zika virus strains MR766 and Paraiba at MOI 1. Coding and noncoding genes were analyzed to determine transcriptional changes 3 days post-infection.

2019-06-18 | GSE113639 | GEO

AGO-iCLIP-seq analysis of Zika infected neural stem cells

Project description:AGO-iCLIP-seq was utilized to characterize the RNAs bound to AGO in human neural stem cells infected with Zika virus strains Paraiba at MOI 1. miRNAs and mRNAs were analyzed to determine changes in RNAs loaded into the RISC 4 days post-infection.

2019-06-18 | GSE113638 | GEO

Transcriptomics in Zika virus-infected human brain organoids

Project description:PolyA+ RNA sequencing of Zika virus-infected human brain organoids at 5 days post-infection.

2017-04-03 | E-MTAB-4811 | biostudies-arrayexpress

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [array]

Project description:We used whole genome expression profiling to analyze the effects of Zika virus (ZIKV) strains Uganda and French Polynesia on the mRNA transcriptome of induced pluripotent stem cell-derived human neural stem cells (long-term self-renewing neuroepithelial-like stem (lt-NES®) cells) - particularly to identify differentially expressed genes which are associated with microcephaly phenotype.

2020-10-31 | GSE157530 | GEO

Zika Virus Targets Human Cortical Neural Precursors and Attenuates Their Growth

Project description:The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly, is an urgent global health concern. The direct target cells of ZIKV in developing human fetuses are not clear. Here we show that ZIKV serially passaged in monkey and mosquito cell lines infects human induced pluripotent stem cells (hiPSCs)-derived cortical neural progenitor cells (hNPCs) with much higher efficiency compared to hiPSCs and hNPC-derived immature cortical neurons. Infected hNPCs produces infectious ZIKV particles. Importantly, ZIKV infection increases cell death and dysregulates cell cycle progression, resulted in attenuated hNPC growth. RNA-sequencing analysis of infected hNPCs further reveals transcriptional dysregulation, notably genes in cell cycle pathways. Our results identify human cortical neural precursors as a major and direct target of ZIKV infection and establish a tractable experimental model system to investigate the impact and mechanism of ZIKV on human brain development and a platform to screen therapeutic compounds.

2016-03-04 | GSE78711 | GEO

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [miRNA-Seq]

Project description:We used next generation sequencing to analyze the effects of Zika virus (ZIKV) strains Uganda and French Polynesia on intracellular and extracellular vesicle (EV) derived miRNA profiles of induced pluripotent stem cell-derived human neural stem cells (long-term self-renewing neuroepithelial-like stem (lt-NES®) cells) - particularly to identify dysregulated miRNAs which are associated with the microcephaly phenotype.

2020-10-31 | GSE157528 | GEO

Transcriptional analysis of primary human monocyte-derived dendritic cells (moDCs) infected with different Zika virus strains and YF17D virus

Project description:Primary human monocytes were isolated and differentiated into moDCs. These moDCs were infected with different Zika virus (ZIKV) strains (namely DN-1, DN-2 and H/PF/2013) and YF17D (as compared to non-infected controls, \\"mock\\") to better understand the gene expression changes induced by these different viruses. moDCs were harvested at 24 hours post-infection and microarray performed with the Affymetrix GeneChip Human Gene 2.0 ST Array.

2018-02-26 | E-MTAB-6192 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data