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Expression data from healthy controls and early stage CRC patient's tumor

ABSTRACT: Metastasis is the major cause of cancer mortality. Up to 25% of early stage sporadic colorectal cancer (CRC) patients succumb to metastasis after curative surgery. We used microarrays to detail gene expression and identified a metastasis-prone signature for early stage CRC. Keywords: RNA expression

ORGANISM(S): Homo sapiens

PROVIDER: GSE9348 | GEO | 2010/02/15

SECONDARY ACCESSION(S): PRJNA103039

REPOSITORIES: GEO

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Expression data from healthy controls and early stage CRC patient's tumor

Project description:Metastasis is the major cause of cancer mortality. Up to 25% of early stage sporadic colorectal cancer (CRC) patients succumb to metastasis after curative surgery. We used microarrays to detail gene expression and identified a metastasis-prone signature for early stage CRC. Keywords: RNA expression Tumors from age- and ethnicity-matched 70 patients and biopsies from 12 healthy controls were used. We aimed to find a metastasis-prone signature for early stage CRC by genome-wide expression profiling of age- and ethnicity-matched patients and healthy controls using the Affymetrix U133 Plus 2 array.

2010-02-15 | E-GEOD-9348 | biostudies-arrayexpress

Transcription profile of colon biopsies from normal (NOR) donors, patients, underwent resection for CRC (M-CRC) and patients carriers of mutations predisposed to HNPCC (HNPC)

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2013-11-30 | E-GEOD-23194 | biostudies-arrayexpress

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Different miRNA expression profiles of CRC with or without lymph node metastasis

Project description:Identifying the exact molecules associated with CRC metastasis may be crucial to understand the process, which might also be translated to the diagnosis and treatment of CRC. In this study, we investigate the association of microRNA expression patterns with the lymph node metastasis of colorectal cancer. To investigate the association of microRNA expression patterns with the lymph node metastasis of colorectal cancer, eight primary colorectal cancer tissues derived from stage II–III colorectal cancer patients with (n = 4) or without (n = 4) lymph node metastasis were collected and the miRNA expression profiles of them were determined using Agilent miRNA microarray. Different miRNA expression profiles were identified in CRC tissues between lymph node metastasis positive and negative group.

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Expression data from early stage CRC patients' tumors [Agilent]

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Project description:This study was conducted in order to identify biomarkers for a prognostic gene expression signature for metastases in early stage CRC.

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Project description:This study was conducted in order to identify biomarkers for a prognostic gene expression signature for metastases in early stage CRC.

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Mucosal biopsies from groups Normal (NOR) and patients who underwent curative large bowel resection for colorectal cancer (M-CRC)

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