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Regulation of mRNA translation and subcellular location controls protein synthesis of key modulators of the DNA damage response during B cell activation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE93576 | GEO | 2017/09/13

SECONDARY ACCESSION(S): PRJNA361161

REPOSITORIES: GEO

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Regulation of mRNA translation and subcellular location controls protein synthesis of key modulators of the DNA damage response during B cell activation [PolyRiboSeq]

Project description:Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation with mitogens, including stress granules that contain the RNA binding protein Tia1. Tia1 binds to a subset of transcripts involved in cell stress, including p53 mRNA, and controls translational silencing and RNA granule localization. DNA damage promotes mRNA relocation and translation in part due to dissociation of Tia1 from its mRNA targets. Upon DNA damage, p53 mRNA is released from stress granules and associates with polyribosomes to increase protein synthesis. Global analysis of cellular mRNA abundance and translation indicates that this is an extended ATM-dependent mechanism to increase protein expression of key modulators of the DNA damage response.

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Regulation of mRNA translation and subcellular location controls protein synthesis of key modulators of the DNA damage response during B cell activation [CLIP-seq]

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Regulation of mRNA translation and subcellular location controls protein synthesis of key modulators of the DNA damage response during B cell activation [RNA-seq]

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Regulation of mRNA translation and subcellular location controls protein synthesis of key modulators of the DNA damage response during B cell activation

Project description:Regulation of mRNA translation and subcellular location controls protein synthesis of key modulators of the DNA damage response during B cell activation

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Cytoplasmic Location of Translation Controls Protein Output [CLIP-seq]

Project description:The cytoplasm contains membrane-bound organelles and membraneless compartments. The TIS granule network is formed through assembly of the RNA-binding protein TIS11B together with its bound mRNAs and associates with a portion of the rough endoplasmic reticulum (ER) – one of the major sites of protein synthesis. Subcellular mRNA localization is widespread in polarized cells. However, it is largely unknown if mRNA localization is also widespread in non-polarized cells and if the location of protein synthesis has biological consequences. To identify compartment-specific cellular functions, we used fluorescent particle sorting to isolate TIS granules, the ER surface, and the cytosol and determined their mRNA contents.

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Project description:Supporting raw data of HEK293T cells proteomics analysis. (related to Horste et al 2023 - DOI: 10.1016/j.molcel.2023.11.025). TMTpro channel used for analysis 132c and 133n.

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