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T cell zone resident macrophages silently dispose of apoptotic cells in the lymph node

ABSTRACT: Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system. In lymph nodes (LN), they are also believed to dispose of apoptotic cells, a critical function usually achieved by macrophages (Mφ) in other tissues. We report a population of tolerogenic Mφ located in the T cell zone of LN. T zone Mφ (TZM) are long lived Mφ seeded after birth and slowly replaced by blood monocytes. We show that TZM but not DC act as the only professional scavengers clearing apoptotic cells in the LN T cell zone. Importantly, we demonstrate that TZM prevent the capture of apoptotic cells by DC and the associated potential noxious activation of T cell immunity. We thus propose a new model in which efferocytosis and T cell activation are uncoupled processes handled by TZM and DC respectively.

ORGANISM(S): Mus musculus

PROVIDER: GSE93592 | GEO | 2017/08/21

SECONDARY ACCESSION(S): PRJNA361253

REPOSITORIES: GEO

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