Molecular Evidence of Chronic Cellular Rejection in C4d and Microvascular Inflammation Negative Transplant Glomerulopathy

ABSTRACT: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1) and/or positive c4d staining. We assessed the molecular profiles of TGP in the absence of microvascular inflammation and C4d staining as compared to TGP with positive MVI and/or C4d. Gene expression profiles of TGP in the absence of microvascular inflammation and C4d lack molecular features of antibody-mediated rejection but suggest chronic cellular rejection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE93659 | GEO | 2017/01/17

SECONDARY ACCESSION(S): PRJNA361485

REPOSITORIES: GEO