Comparison of the transcriptomic profile of P. falciparum reactive polyfunctional and IFNg monofunctional human CD4 T cells

ABSTRACT: Pathogen-specific polyfunctional T cell responses have been associated with favorable clinical outcomes but it is not known whether polyfunctional T cells are distinct from monofunctional cytokine producing T cells. In this study we compared the transcriptomic profile of P. falciparum reactive polyfunctional and IFNg monofunctional CD4 T cells by microarray analysis and show that polyfunctional CD4 T cells are associated with a unique transcriptomic signature.

ORGANISM(S): Homo sapiens

PROVIDER: GSE93664 | GEO | 2017/01/17

SECONDARY ACCESSION(S): PRJNA361491

REPOSITORIES: GEO