Dataset Information


Viral and Cellular N6-methyladenosine (m6A) Epitranscriptomes in KSHV Life Cycle

ABSTRACT: Tan et al. discovered abundant conserved N6-methyladenosine (m6A) modifications on KSHV transcripts during latent and productive infection in different cell types. They also show that m6A readers YTHDF2 and YTHDF3 mediate KSHV replication, and KSHV optimizes both phases of viral replication by reprograming cellular epitranscriptome to regulate distinct signaling pathways. Overall design: m6A epitranscriptome profiles of four uninfected cell types, five latently infected cell types, and three lytic cell types. Each cell type has an immunoprecipitated (IP) and input sample.

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)


PROVIDER: GSE93676 | GEO | 2017-10-31



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Viral and cellular N<sup>6</sup>-methyladenosine and N<sup>6</sup>,2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.

Tan Brandon B   Liu Hui H   Zhang Songyao S   da Silva Suzane Ramos SR   Zhang Lin L   Meng Jia J   Cui Xiaodong X   Yuan Hongfeng H   Sorel Océane O   Zhang Shao-Wu SW   Huang Yufei Y   Gao Shou-Jiang SJ  

Nature microbiology 20171106 1

N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) and N<sup>6</sup>,2'-O-dimethyladenosine (m<sup>6</sup>Am) modifications (m<sup>6</sup>A/m) of messenger RNA mediate diverse cellular functions. Oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) has latent and lytic replication phases that are essential for the development of KSHV-associated cancers. To date, the role of m<sup>6</sup>A/m in KSHV replication and tumorigenesis is unclear. Here, we provide mechanistic insights by examining the v  ...[more]

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