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MicroRNA15a/16-1 represses the development of colorectal cancer by restraining the recruitment of immunosuppressive B lymphocytes

ABSTRACT: B lymphocytes are emerging as abundant cellular components in various tumors; however, the mechanisms underlying their tumor-infiltration and their subsequent action remain to be extensively elucidated. In the present study, using a murine model of primary colorectal cancer (CRC), we found that deficiency of the small non-coding RNA cluster, microRNA15a/16-1 (miR-15a/16-1), promoted the accumulation of immunosuppressive B cells in neoplastic tissues, resulting in the repression of the proliferation and function of CD8+ T cells, and in the promotion of CRC.

ORGANISM(S): Mus musculus

PROVIDER: GSE93821 | GEO | 2019/01/01

REPOSITORIES: GEO

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