Heteroplasmy between wild type mitochondrial DNA variants is detrimental and shorten life span

ABSTRACT: We evaluated here the physiological consequences of the generation of heteroplasmic embryos by mix of two wild type mtDNAs in the same zygote. In this animal model, mtDNA heteroplasmy is actively combated during germ-line transmission, embryonic development and somatic life of most differentiated cells. mtDNA heteroplasmy alone, even when both mtDNA types are individually non-pathogenic, causes a disease affecting mainly those tissues that are not able to reduce their heteroplasmy: heart, lung and skeletal muscle.

ORGANISM(S): Mus musculus

PROVIDER: GSE93920 | GEO | 2020/01/01

REPOSITORIES: GEO