Oxidative stress elicits a rapid and global RNA polymerase II transcriptional response in human cells [ChIP-Seq]

ABSTRACT: Using ChIP-Seq, we show that hydrogen peroxide causes rapid accumulation of Pol II at promoters and enhancers. Over time, a fraction of accumulated Pol II loses NELF and creeps downstream. In GSE100740, we also compared nuclear walk-on results with PRO-Seq, both of which were performed using nuclei from DMSO- and flavopiridol-treated cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE93931 | GEO | 2017/08/07

SECONDARY ACCESSION(S): PRJNA362854

REPOSITORIES: GEO