Genomics

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Expression data from heart tissues of minipig with myocardial infarction and treated or untreated with myoblast transplantation


ABSTRACT: Myocardial infarction (MI) is a highly prevalent cardiac emergency, which results in adverse left ventricular remodeling exacerbating progressive heart failure. Inflammation in post-MI is necessary for myocyte repair and wound healing. However, it is also a key component of subsequent heart failure pathology. Myoblasts transplantation after MI have been fulfilled a good effect on cardiac repair, but the occasion, complications of transplantation, and the underlying mechanisms have not been fully elucidated. Here, we found that myoblast transplantation decreased the expression of many pro-inflammatory genes and the activation of inflammation-related signal pathway in heart tissue of pig post MI, which mainly contributed to the improved heart function and attenuated damage of myocardial cells.

ORGANISM(S): Sus scrofa

PROVIDER: GSE94151 | GEO | 2017/01/28

SECONDARY ACCESSION(S): PRJNA369089

REPOSITORIES: GEO

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