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Genome-wide analysis of RNA-binding protein PSF-associated transcripts in prostate cancer

ABSTRACT: Prostate cancer is the most common cancer in men and androgen receptor (AR) downstream signalings promote prostate cancer cell proliferation. PSF is an RNA-binding protein which is involved in AR signaling. To investigate the role of PSF, we performed RNA immunoprecipitation (RIP) and crosslinking immunoprecipitation (CLIP) sequence analysis in AR-positive prostate cancer cell line, LNCaP. In addition, we used hormone-refractory prostate cancer model cells 22Rv1 and long term androgen deprivation (LTAD) cells to explore the differences of PSF function in prostate cancer progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE94243 | GEO | 2017/12/24

SECONDARY ACCESSION(S): PRJNA369120

REPOSITORIES: GEO

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