Transcriptome profiles of liver biopsy tissues from sever alcoholic hepatitis patients (derivation cohort)

ABSTRACT: Corticosteroids are the current standard of care to improve short-term mortality in severe alcoholic hepatitis (AH), although nearly 40% of the patients do not respond and accurate pre-treatment predictors are lacking. We developed 123-gene prognostic score based on molecular and clinical variables before initiation of corticosteroids. Furthermore, The gene signature was implemented in an FDA-approved platform (NanoString), and verified for technical validity and prognostic capability. Here we demonstrated that a Nanostring-based gene expressoin risk classificatoin is useful to predict mortality in patients with severe alcoholic hepatitis who were treated by corticosteroid

ORGANISM(S): Homo sapiens

PROVIDER: GSE94397 | GEO | 2018/02/18

REPOSITORIES: GEO