MicroRNA Profiling of Endothelial Cells

ABSTRACT: In this study, the miRNA expression of human vascular endothelial cells from tissue-derived cells and cultured cells were profiled using miRNA sequencing. The data analysis revealed a striking switch in endothelial miRNA profile as the cells adapted from tissue to cell culture environment and the overall miRNA expression decreased significantly in cultured endothelial cells compared to tissue-derived endothelial cells. In addition to changes in mechanosensitive miRNA expression, alterations in senescence-associated and endothelial-to-mesenchymal-transition-associated miRNAs were observed in aging cells. Collectively, the data illustrates the plasticity of endothelial cells, and elucidates the multifaceted nature of the cell-specific miRNA profiles, clearly emphasising that the cellular miRNA profile consists of fluid collection of miRNAs, which mirror the prevailing cellular status.

ORGANISM(S): Homo sapiens

PROVIDER: GSE94410 | GEO | 2017/09/09

SECONDARY ACCESSION(S): PRJNA369614

REPOSITORIES: GEO